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Brain surgery alternative shows promise for Parkinson’s disease

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The surgery could offer a new option for patients whose symptoms are poorly controlled by medications

A scalpel-free alternative to brain surgery has the potential to benefit people with Parkinson’s disease symptoms that are much more severe on one side of the body, according to new research.

The approach, which uses a technology called focused ultrasound, could offer a new option for patients whose symptoms are poorly controlled by medications and those who cannot or do not wish to undergo traditional brain surgery.

Jeff Elias, a neurosurgeon at UVA Health, said: “This small brain region, the subthalamic nucleus, had a very strong and potent effect on parkinsonian symptoms when we targeted it with precise, focused ultrasound energy.

“The key for the ultimate adoption of this new procedure will be further refinements of the technology to ensure reliability and safety.”

The technology focuses sound waves inside the body, allowing doctors to interrupt faulty brain circuits or destroy unwanted tissue. Magnetic-resonance imaging (MRI) allows doctors to monitor the procedure in real time – and to make adjustments as needed to obtain the best patient outcomes.

To determine if the technology could benefit patients with asymmetrical Parkinson’s symptoms, Elias and Binit Shah collaborated with Spain’s Centro Intregral de Neurociencias to evaluate the approach in 40 volunteers in a randomised, double-blinded study.

27 study participants received treatment with focused ultrasound, while 13 others received a simulated treatment, so that the researchers could compare the results between the real procedure and the placebo. The average age of study participants was 57.

The volunteers’ symptoms before and after the procedure were assessed on a scale of 1-44. Those who received the focused ultrasound procedure saw an improvement of 10 points, while those who received the sham treatment saw a difference of less than two points.

The study also looked at the safety of the procedure. Side effects included unwanted movements, muscle weakness, speech disturbances and difficulty walking. In most cases, these were temporary, but some effects persisted in six patients a year later.

Shah, also of UVA Health, said: “Parkinson’s disease affects patients in more ways than just tremor.

“The current FDA approval for focused ultrasound in Parkinson’s disease treats only tremor.

“Targeting this new area allows us to improve tremor but also get more overall benefit for our patients than we previously were able to achieve.”

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3 Comments

3 Comments

  1. Pingback: The future of robot-assisted surgery - Health Tech World

  2. Pingback: Non-invasive brain stimulation helps to ease tremors - Health Tech World

  3. Pingback: Specialist new tool will help surgeons spot epilepsy in the brain

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